BDBM597663 7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-pyrrolo[2,3-d] pyrimidin-4-amine::US11603374, Example 18

SMILES Nc1ncnc2n(cc(-c3cc(on3)C3CC3)c12)C1CCC1

InChI Key InChIKey=PTKFUPUNSIPOQO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 597663   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 0.900nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 1.40nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 0.700nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 7.20nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 3.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent