BDBM597649 US11603374, Example 4

SMILES CC(C)(C)n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12

InChI Key InChIKey=ZKTHKOCQUXQEGT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 597649   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM597649(US11603374, Example 4)
Affinity DataIC50: 0.800nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597649(US11603374, Example 4)
Affinity DataIC50: 2.30nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597649(US11603374, Example 4)
Affinity DataIC50: 1.40nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597649(US11603374, Example 4)
Affinity DataIC50: 2.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597649(US11603374, Example 4)
Affinity DataIC50: 10.4nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent