BDBM597460 ((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,7,8,9-hexahydro- 2H-5,9-epiminocycloocta[c]pyrazol-10-yl)(2-methylimidazo[1,2- a]pyridin-3-yl)methanone;::US11597728, Example 347::US11597728, Example 359

SMILES Cc1nc2ccccn2c1C(=O)N1[C@H]2CCC[C@@H]1c1nn(C)c(c1C2)-c1cc(F)c(F)c(F)c1

InChI Key InChIKey=GSQAJOMZJVGOAI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 597460   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597460(US11597728, Example 359 | ((5R,9S)-2-Methyl-3-(3,4...)
Affinity DataIC50: 0.680nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
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TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597460(US11597728, Example 359 | ((5R,9S)-2-Methyl-3-(3,4...)
Affinity DataIC50: 10.1nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
Go to US Patent