BDBM597367 ((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,7,8,9-hexahydro- 2H-5,9-epiminocycloocta[c]pyrazol-10-yl)(quinazolin-4- yl)methanone;::US11597728, Example 254

SMILES Cn1nc2[C@H]3CCC[C@@H](Cc2c1-c1cc(F)c(F)c(F)c1)N3C(=O)c1ncnc2ccccc12

InChI Key InChIKey=OWGAVVYKNDWAMY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 597367   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM597367(((5R,9S)-2-Methyl-3-(3,4,5-trifluorophenyl)-4,5,6,...)
Affinity DataIC50: 0.430nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
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