BDBM596415 US11591338, Example 91

SMILES CC(C)C(=O)N1CCC(CC1)c1cc(c([nH]1)C(\N)=N/C=N)-c1ccc(NC(=O)c2cn(C(C)C)c(=O)n(-c3cccc(c3)C#N)c2=O)cc1

InChI Key InChIKey=XNWXZQJDSKMTDA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 596415   

TargetTyrosine-protein kinase receptor UFO(Human)
Incyte

US Patent
LigandPNGBDBM596415(US11591338, Example 91)
Affinity DataIC50: 100nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
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TargetTyrosine-protein kinase Mer(Human)
Incyte

US Patent
LigandPNGBDBM596415(US11591338, Example 91)
Affinity DataIC50: 7.5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
Incyte

US Patent
LigandPNGBDBM596415(US11591338, Example 91)
Affinity DataIC50: 5nMAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
Go to US Patent