BDBM595739 US11591331, Example 64::US20240228490, Example 45

SMILES CNC(=O)c1ccc(cn1)C1=CCN(Cc2cnc3cc(C4CC4)c(=O)[nH]c3c2)CC1

InChI Key InChIKey=AJOGLCNLWZDRDX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 595739   

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595739(US11591331, Example 64 | US20240228490, Example 45)
Affinity DataIC50: 5.5nMAssay Description:Assays based on fluorescent polarization (FP) have been widely utilized in drug discovery due to the homogenous format, robust performance and lack o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM595739(US11591331, Example 64 | US20240228490, Example 45)
Affinity DataIC50: 7.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595739(US11591331, Example 64 | US20240228490, Example 45)
Affinity DataIC50: 0.800nMAssay Description:1. Experimental ObjectiveThe experimental objective of this Test Example is to determine the inhibitory activity of the compounds on PARP1 enzyme.2. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
Go to US Patent