BDBM595711 US11591331, Example 22A::US20240287094, Example 2

SMILES CCc1cc2ncc(CN3CCN4[C@@H](COc5nc(ccc45)C(=O)NC)C3)cc2[nH]c1=O

InChI Key InChIKey=DXIMOTGAHXBNFM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 595711   

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595711(US11591331, Example 22A | US20240287094, Example 2)
Affinity DataIC50: 1.60nMAssay Description:Assays based on fluorescent polarization (FP) have been widely utilized in drug discovery due to the homogenous format, robust performance and lack o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM595711(US11591331, Example 22A | US20240287094, Example 2)
Affinity DataIC50: 3.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595711(US11591331, Example 22A | US20240287094, Example 2)
Affinity DataIC50: 11nMAssay Description:In vitro binding activities for PARP1 and PARP2 were tested by the following method.I. Materials and instruments1. PARP1 recombinant protein (Sino Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM595711(US11591331, Example 22A | US20240287094, Example 2)
Affinity DataIC50: 1.78E+3nMAssay Description:In vitro binding activities for PARP1 and PARP2 were tested by the following method.I. Materials and instruments1. PARP1 recombinant protein (Sino Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2024
Entry Details
Go to US Patent