BDBM595701 US11591331, Example 8::US20240228490, Example 1::US20250034168, Compound 14

SMILES CCc1cc2ncc(CN3CCC(=CC3)c3ccc(nc3)C(=O)NC)cc2[nH]c1=O

InChI Key InChIKey=BOKCRBOZYPDNIC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 595701   

TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595701(US11591331, Example 8 | US20240228490, Example 1 |...)
Affinity DataIC50: 6.5nMAssay Description:Assays based on fluorescent polarization (FP) have been widely utilized in drug discovery due to the homogenous format, robust performance and lack o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM595701(US11591331, Example 8 | US20240228490, Example 1 |...)
Affinity DataIC50: 5.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
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TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595701(US11591331, Example 8 | US20240228490, Example 1 |...)
Affinity DataIC50: 0.930nMAssay Description:1. Experimental ObjectiveThe experimental objective of this Test Example is to determine the inhibitory activity of the compounds on PARP1 enzyme.2. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase 1(Human)
Xinthera

US Patent
LigandPNGBDBM595701(US11591331, Example 8 | US20240228490, Example 1 |...)
Affinity DataIC50: 0.590nMAssay Description:PARP-1 chemical fluorescence detection kit was purchased from BPS Bioscience. The histone solution in the kit was diluted 5× with 1×PBS, and 25 μL of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Xinthera

US Patent
LigandPNGBDBM595701(US11591331, Example 8 | US20240228490, Example 1 |...)
Affinity DataIC50: 31nMAssay Description:PARP2 and PARP7 chemical fluorescence detection kits were both purchased from BPS Bioscience. The histone solution in the kit was diluted 5× with 1×P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
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TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Xizang Haisco Pharmaceutical

US Patent
LigandPNGBDBM595701(US11591331, Example 8 | US20240228490, Example 1 |...)
Affinity DataIC50: 40nMAssay Description:PARP2 and PARP7 chemical fluorescence detection kits were both purchased from BPS Bioscience. The histone solution in the kit was diluted 5× with 1×P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
Go to US Patent