BDBM595300 US11584714, Compound 1388::US12195427, Compound 1388

SMILES C[C@H](NC(=O)C1=CC(C2=C(CC(C)(C)CC2=O)N1)c1ccccc1)C(=O)NCc1ccc(N)nc1C

InChI Key InChIKey=CAIAPMWVJCGFLJ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 595300   

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595300(US11584714, Compound 1388 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595300(US11584714, Compound 1388 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595300(US11584714, Compound 1388 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595300(US11584714, Compound 1388 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595300(US11584714, Compound 1388 | US12195427, Compound 1...)
Affinity DataKi: >2.50E+4nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595300(US11584714, Compound 1388 | US12195427, Compound 1...)
Affinity DataKi: >2.50E+4nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent