BDBM595277 US11584714, Compound 1365::US12195427, Compound 1365::US12351648, Compound 1365

SMILES C[C@H](NC(=O)[C@H]1C[C@H](CCN1)c1ccccc1)C(=O)NCc1cc(Cl)cc(C)c1O

InChI Key InChIKey=BKLWLDAVXPMOPB-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 595277   

TargetC-type lectin domain family 4 member K(Human)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: <500nMAssay Description:The MASP-2 assay protocol was carried out as follows. Test compounds were serially diluted in DMSO and then 100 nL of each dilution was transferred t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Human)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: <500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetMannan-binding lectin serine protease 2(Mouse)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: <500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: >2.50E+4nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetProthrombin(Human)
Omeros

US Patent
LigandPNGBDBM595277(US11584714, Compound 1365 | US12195427, Compound 1...)
Affinity DataKi: >2.50E+4nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent