BDBM594493 US11584747, Example 300::US11584747, Example 301

SMILES CCC(N1C[C@H](C)N(C[C@H]1CC)c1nc(=O)n(C)c2ccc(nc12)C#N)c1ccc(cc1)C1CC1

InChI Key InChIKey=JCMBFPCVVCXWKC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 594493   

TargetDiacylglycerol kinase alpha [9-727](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594493(US11584747, Example 300 | US11584747, Example 301)
Affinity DataIC50: 13nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594493(US11584747, Example 300 | US11584747, Example 301)
Affinity DataIC50: 22nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase alpha [9-727](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594493(US11584747, Example 300 | US11584747, Example 301)
Affinity DataIC50: 130nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM594493(US11584747, Example 300 | US11584747, Example 301)
Affinity DataIC50: 430nMAssay Description:The reactions were carried out in 50 mM MOPS pH 7.5, 100 mM NaCl, 10 mM MgCl2, 1 μM CaCl2, and 1 mM DTT (assay buffer). The reactions using a de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent