BDBM594206 US11584746, Compound I-23

SMILES CN1CCC(CC1)n1cc(cn1)-c1ccc2Nc3ccc(F)cc3N(Cc3cccc(Cl)c3)C(=O)c2c1

InChI Key InChIKey=XPAZNAABBJKCRN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 594206   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594206(US11584746, Compound I-23)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent