BDBM593531 N-({5-[5-(difluoromethyl)-1,3,4-oxadiazol-2- yl]-1,3-thiazol-2-yl}methyl)-N-(5- fluoropyridin-3-yl)-2-methylpropane-1- sulfonamide::US11578066, Compound I-223::US20230381148, Compound I-223::US20240269137, Compound I-223

SMILES CC(C)CS(=O)(=O)N(Cc1ncc(s1)-c1nnc(o1)C(F)F)c1cncc(F)c1

InChI Key InChIKey=YNOCEKSUYBHMKW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 593531   

TargetHistone deacetylase 6(Human)
Tenaya Therapeutics

US Patent
LigandPNGBDBM593531(US11578066, Compound I-223 | N-({5-[5-(difluoromet...)
Affinity DataIC50: 5.63nMAssay Description:Table 13: The compounds disclosed herein, in particular those of Formula (I), were synthesized according to methods disclosed in PCT/US2020/066439, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Tenaya Therapeutics

US Patent
LigandPNGBDBM593531(US11578066, Compound I-223 | N-({5-[5-(difluoromet...)
Affinity DataIC50: 5.63nMAssay Description:The compounds disclosed herein were tested for potency against HDAC6 and selectivity against HDAC1 in a biochemical assay. A biochemical assay was ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Tenaya Therapeutics

US Patent
LigandPNGBDBM593531(US11578066, Compound I-223 | N-({5-[5-(difluoromet...)
Affinity DataIC50: 5.63nMAssay Description:A biochemical assay was adopted using a luminescent HDAC-Glo I/II assay (Promega) and measured the relative activity of HDAC6 and HDAC1 recombinant p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent