BDBM593496 N-({5-[5-(difluoromethyl)-1,3,4-oxadiazol-2- yl]-1,3-thiazol-2-yl)methyl)-N-(5- fluoropyridin-3-yl)-2-[(1R,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]ethane-1- sulfonamide::US11578066, Compound I-188::US20230381148, Compound I-188::US20240269137, Compound I-188
SMILES FC(F)c1nnc(o1)-c1cnc(CN(c2cncc(F)c2)S(=O)(=O)CCN2C[C@H]3C[C@@H]2CO3)s1
InChI Key InChIKey=HYPMSYCLPYENKN-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 593496
Affinity DataIC50: 15.1nMAssay Description:Table 13: The compounds disclosed herein, in particular those of Formula (I), were synthesized according to methods disclosed in PCT/US2020/066439, p...More data for this Ligand-Target Pair
Affinity DataIC50: 15.1nMAssay Description:The compounds disclosed herein were tested for potency against HDAC6 and selectivity against HDAC1 in a biochemical assay. A biochemical assay was ad...More data for this Ligand-Target Pair
Affinity DataIC50: 15.1nMAssay Description:A biochemical assay was adopted using a luminescent HDAC-Glo I/II assay (Promega) and measured the relative activity of HDAC6 and HDAC1 recombinant p...More data for this Ligand-Target Pair