BDBM593021 (R)-6-(2,2-difluorocyclopropane-1-carboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide::US11578058, Compound 7::US11578058, Compound 8

SMILES CNC(=O)c1nnc(NC(=O)[C@H]2CC2(F)F)cc1Nc1cccc(-c2ncn(C)n2)c1OC

InChI Key InChIKey=DFFFANVCCDREBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 593021   

TargetTyrosine-protein kinase JAK2(Human)
Beijing Innocare Pharma Tech

US Patent
LigandPNGBDBM593021(US11578058, Compound 7 | US11578058, Compound 8 | ...)
Affinity DataIC50: 8.50E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Beijing Innocare Pharma Tech

US Patent
LigandPNGBDBM593021(US11578058, Compound 7 | US11578058, Compound 8 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Beijing Innocare Pharma Tech

US Patent
LigandPNGBDBM593021(US11578058, Compound 7 | US11578058, Compound 8 | ...)
Affinity DataIC50: 7.50E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Beijing Innocare Pharma Tech

US Patent
LigandPNGBDBM593021(US11578058, Compound 7 | US11578058, Compound 8 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
Go to US Patent