BDBM5929 (+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-3-piperidinecarboxamide::BMS-387032 analog 19::CHEMBL297570::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-3-carboxamide

SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCNC3)s2)o1

InChI Key InChIKey=USAKOZCUIYTREA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5929   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb

LigandPNGBDBM5929(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 83nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5929(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 550nMAssay Description:Inhibition of CDK9-mediated RNA pol 2 phosphorylation at ser2 in human HCT116 cells after 16 hrs by HCS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5929(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfan...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK2/Cyclin A by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed