BDBM592822 3-chloro-N-((1R,2R,4S)-7-cyano-7- azabicyclo[2.2.1]heptan-2-yl)-3'- (cyanomethyl)-2'-fluoro[biphenyl]-4- carboxamide::US11572374, Example 20-10::US11572374, Example 20-16

SMILES Clc1cc(ccc1C(=O)N[C@@H]1C[C@@H]2CC[C@H]1N2C#N)-c1cccc(CC#N)c1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 592822   

LigandPNGBDBM592822(US11572374, Example 20-10 | 3-chloro-N-((1R,2R,4S)...)
Affinity DataIC50: 194nMAssay Description:USP30 inhibition was tested with recombinant human USP30 using the fluorescent substrate Ubiquitin-Rhodamine 110 (UBPBio) in 1536-well format. Compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
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LigandPNGBDBM592822(US11572374, Example 20-10 | 3-chloro-N-((1R,2R,4S)...)
Affinity DataIC50: 47nMAssay Description:USP30 inhibition was tested with recombinant human USP30 using the fluorescent substrate Ubiquitin-Rhodamine 110 (UBPBio) in 1536-well format. Compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
Go to US Patent