BDBM59227 Pyrazolopyrimidone analog, RGB-286147

SMILES CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12

InChI Key InChIKey=RSQPNXBTPUXMQN-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 59227   

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 48nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 15nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 839nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 282nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 51nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 71nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 754nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 71nMAssay Description:Inhibition of Cdk7/H/MAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 282nMAssay Description:Inhibition of Cdk6/cyclin D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 9nMAssay Description:Inhibition of Cdk9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50: 754nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed