BDBM592070 US11566028, Example 63::US11566028, Example 9

SMILES CNC(=O)c1cncc(c1)-c1cnn2cc(-c3cnn(c3)C(C)C)c(O[C@H]3CCOC3)nc12

InChI Key InChIKey=XKKGIGFZDVPVNO-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 592070   

TargetFibroblast growth factor receptor 1(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 145nMAssay Description:Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST tagged recombinant human FGFR2 (400 to 821 residues) expressed in an Sf9 infected baculovirus expression system using bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 177nMAssay Description:Inhibition of FGFR3 in human whole blood assessed as reduction in phosphorylated ERK incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsomes CYP3A4 using midazolam or testosterone as substrate in presence of NADPH regenerating system by LC-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human liver microsomes CYP3A4 using midazolam or testosterone as substrate in presence of NADPH regenerating system by LC-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of recombinant human FGFR3 V555M mutant using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human FGFR3 V555M mutant using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human FGFR1 using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 115nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592070(US11566028, Example 9 | US11566028, Example 63)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent