BDBM592064 US11566028, Example 3

SMILES CNC(=O)c1cncc(c1)-c1cnn2cc(-c3cnn(C)c3)c(OC3CCOC3)nc12

InChI Key InChIKey=YYQDOAWXLMOOHX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 592064   

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphorylation using FRET m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 115nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal His-Avi tagged recombinant human FGFR3 (447 to 761 residues) expressed in an Sf9 infected baculovirus expression system usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Mouse)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 29nMAssay Description:Inhibition of TEL-FGFR3 in mouse BaF3 cells incubated for 125 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM592064(US11566028, Example 3)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human liver microsomes CYP3A4 using midazolam or testosterone as substrate in presence of NADPH regenerating system by LC-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed