BDBM59206 Adenosine analog, 11

SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)NCCO

InChI Key InChIKey=YLPQAZPIFSHMAY-UHFFFAOYSA-N

Data  13 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 59206   

TargetAdenosine receptor A2b(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataEC50:  942nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataEC50:  948nMAssay Description:Agonist activity at human A2B adenosine receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  12.8nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  12.8nMAssay Description:Displacement of 3[H]R-PIA from human A1 adenosine receptor expressed in CHO cells after 60 mins by Liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  41.7nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  505nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  505nMAssay Description:Displacement of 3[H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cells after 60 mins by Liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5-N-ethylcarboxamidoadenosine from human A2A adenosine receptor expressed in HEK293 cell m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  2.11E+3nM ΔG°:  -7.74kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  3.87E+3nM ΔG°:  -7.38kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  9.45E+3nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  9.45E+3nMAssay Description:Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cells after 60 mins gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  9.45E+3nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from human A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandPNGBDBM59206(Adenosine analog, 11)
Affinity DataKi:  1.33E+4nM ΔG°:  -6.65kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed