BDBM59194 4-aminothiazole, 2.0

SMILES c1cc(cc(c1)[N+](=O)[O-])C(=O)c2c(nc(s2)Nc3ccc(cc3)Cl)N

InChI Key InChIKey=YQRVBHMYUSGXHL-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 59194   

TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59194(4-aminothiazole, 2.0)
Affinity DataKi:  660nM IC50: 2.00E+3nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59194(4-aminothiazole, 2.0)
Affinity DataKi:  690nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)