BDBM591353 US11566007, Example A31

SMILES CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3cc(O)cc(c3)-c3ccc1c2c3)NC(=O)[C@H](C(C)C)N1CCC2(CN(C2)C(=O)C=C)C1=O)-c1ccccc1CCOC

InChI Key InChIKey=RNQWJFUTDARQRO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 591353   

TargetGTPase KRas [G13C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591353(US11566007, Example A31)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
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TargetGTPase KRas [G12V](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591353(US11566007, Example A31)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12S](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591353(US11566007, Example A31)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetGTPase KRas(Human)
Revolution Medicines

US Patent
LigandPNGBDBM591353(US11566007, Example A31)
Affinity DataIC50: 5.50E+3nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591353(US11566007, Example A31)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591353(US11566007, Example A31)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent