BDBM591294 (S)-2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)isoquinolin-3- yl)amino)-4,6-dimethyl-5,6-dihydro-4H- pyrazolo[1,5-d][1,4]diazepin-7(8H)-one (Absolute stereochemistry arbitrarily assigned)::US11566003, Compound 361

SMILES C[C@H]1CN(C)C(=O)Cn2nc(Nc3cc4cc(c(F)c(N)c4cn3)-c3cnccc3C)cc12

InChI Key InChIKey=PVQUMNRWYYNXEH-UHFFFAOYSA-N

Data  1 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 591294   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

US Patent

LigandBDBM591294((S)-2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)...)Copy SMILESCopy InChI

Affinity DataKi:  0.0330nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2023
Entry Details
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