BDBM591243 (R)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fluoroisoquinolin- 3-yl)amino)-4-fluoro-6-methyl-5,6- dihydro-4H-pyrazolo[1,5- d][1,4]diazepin-7(8H)-one (Absolute stereochemistry arbitrarily assigned)::US11566003, Compound 309

SMILES CN1C[C@@H](F)c2cc(Nc3cc4cc(c(F)c(N)c4cn3)-c3cncc(N)c3C)nn2CC1=O

InChI Key InChIKey=UZYAAUPDBGHHCQ-UHFFFAOYSA-N

Data  1 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 591243   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

US Patent

LigandBDBM591243((R)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-...)Copy SMILESCopy InChI

Affinity DataKi:  0.0170nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2023
Entry Details
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