BDBM591237 (E)-2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)isoquinolin-3- yl)amino)-6-methyl-4-((1-methyl-1H- pyrazol-4-yl)methylene)-5,6-dihydro- 4H-pyrazolo[1,5-d][1,4]diazepin-7(8H)- one::US11566003, Compound 303

SMILES CN1C\C(=C/c2cnn(C)c2)c2cc(Nc3cc4cc(c(F)c(N)c4cn3)-c3cnccc3C)nn2CC1=O

InChI Key InChIKey=NLRDMWPDTDJLLY-UHFFFAOYSA-N

Data  1 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 591237   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

US Patent

LigandBDBM591237((E)-2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)...)Copy SMILESCopy InChI

Affinity DataKi:  0.0240nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2023
Entry Details
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