BDBM591222 2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fluoroisoquinolin- 3-yl)amino)-6-(cyclopropylmethyl)-5,6- dihydro-4H-pyrazolo[1,5- d][1,4]diazepin-7(8H)-one::US11566003, Compound 288

SMILES Cc1c(N)cncc1-c1cc2cc(Nc3cc4CCN(CC5CC5)C(=O)Cn4n3)ncc2c(N)c1F

InChI Key InChIKey=TUTNLRDBEYCJPK-UHFFFAOYSA-N

Data  1 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 591222   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Genentech

US Patent

LigandBDBM591222(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)Copy SMILESCopy InChI

Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2023
Entry Details
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