BDBM591135 2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)isoquinolin-3- yl)amino)-4,6-dimethyl-5,6-dihydro- 4H-pyrazolo[1,5-d][1,4]diazepin- 7(8H)-one::US11566003, Compound 227

SMILES CC1CN(C)C(=O)Cn2nc(Nc3cc4cc(c(F)c(N)c4cn3)-c3cnccc3C)cc12

InChI Key InChIKey=PVQUMNRWYYNXEH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 591135   

LigandPNGBDBM591135(2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)isoq...)
Affinity DataKi:  0.0780nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
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LigandPNGBDBM591135(2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)isoq...)
Affinity DataKi:  0.0790nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent