BDBM588234 US11542259, Compound 128::methyl 4-[2-chloro-4-[[1-[(4- fluorophenyl)carbamoyl]- cyclopropanecarbonyl]- amino]phenoxy]- 7-methoxyquinoline-6- carboxylate

SMILES COC(=O)c1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3Cl)ccnc2cc1OC

InChI Key InChIKey=MDXKNSXZZVDCES-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 588234   

LigandPNGBDBM588234(methyl 4-[2-chloro-4-[[1-[(4- fluorophenyl)carbamo...)
Affinity DataIC50: 10nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEO ID NO. 43) 10 mM m...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
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LigandPNGBDBM588234(methyl 4-[2-chloro-4-[[1-[(4- fluorophenyl)carbamo...)
Affinity DataIC50: 10nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM588234(methyl 4-[2-chloro-4-[[1-[(4- fluorophenyl)carbamo...)
Affinity DataIC50: 10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEO ID NO...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent