BDBM588175 (E)-1-[4-[[6-[2-(3- chloroanilino)pyrimidin- 5-yl]pyrazin-2- yl]amino]-1- piperidyl]-4- (dimethylamino)but-2- en-1-one::US11542249, Example 46

SMILES CN(C)C\C=C\C(=O)N1CCC(CC1)Nc1cncc(n1)-c1cnc(Nc2cccc(Cl)c2)nc1

InChI Key InChIKey=NCTZVOWBHNAGHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588175   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588175((E)-1-[4-[[6-[2-(3- chloroanilino)pyrimidin- 5-yl]...)
Affinity DataIC50: 5nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588175((E)-1-[4-[[6-[2-(3- chloroanilino)pyrimidin- 5-yl]...)
Affinity DataIC50: 6.04E+3nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent