BDBM588174 (E)-1-[4-[[6-[2-(3-chlorophenoxy)pyrimidin-5-yl]pyrazin-2-yl]amino]-1-piperidyl]-4-(dimethylamino)but-2-en-1-one::US11542249, Example 45

SMILES CN(C)C\C=C\C(=O)N1CCC(CC1)Nc1cncc(n1)-c1cnc(Oc2cccc(Cl)c2)nc1

InChI Key InChIKey=CSRNKRHVIIQUIB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588174   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588174((E)-1-[4-[[6-[2-(3-chlorophenoxy)pyrimidin-5-yl]py...)
Affinity DataIC50: 43.8nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
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TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588174((E)-1-[4-[[6-[2-(3-chlorophenoxy)pyrimidin-5-yl]py...)
Affinity DataIC50: 5.26E+4nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent