BDBM588171 1-[3-[[6-[2-(3- methoxyphenoxy) pyrimidin-5- yl]pyrazin-2- yl]amino]azetidin- l-yl]prop-2-en-1- one::US11542249, Example 42

SMILES COc1cccc(Oc2ncc(cn2)-c2cncc(NC3CN(C3)C(=O)C=C)n2)c1

InChI Key InChIKey=PSIBRANOSXUZQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588171   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588171(1-[3-[[6-[2-(3- methoxyphenoxy) pyrimidin-5- yl]py...)
Affinity DataIC50: 19.4nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588171(1-[3-[[6-[2-(3- methoxyphenoxy) pyrimidin-5- yl]py...)
Affinity DataIC50: 2.82E+3nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent