BDBM588168 1-[(3S)-3-[[6-[2-[3- (difluoromethoxy) anilino]pyrimidin-5- yl]pyrazin-2- yl]amino]pyrrolidin- 1-yl]prop-2-en-1- one::US11542249, Example 39

SMILES FC(F)Oc1cccc(Nc2ncc(cn2)-c2cncc(N[C@H]3CCN(C3)C(=O)C=C)n2)c1

InChI Key InChIKey=LEVDKHIBYIKALJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588168   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588168(1-[(3S)-3-[[6-[2-[3- (difluoromethoxy) anilino]pyr...)
Affinity DataIC50: 5.60nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
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TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588168(1-[(3S)-3-[[6-[2-[3- (difluoromethoxy) anilino]pyr...)
Affinity DataIC50: 1.46E+3nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent