BDBM588161 1-[(2S,3R)-3-[[6- [2-(3- chlorophenoxy) pyrimidin-5-yl]pyrazin- 2-yl]amino]-2- methyl-azetidin-1- yl]prop-2-en-1-one, Isomer 1::US11542249, Example 32

SMILES C[C@H]1[C@@H](CN1C(=O)C=C)Nc1cncc(n1)-c1cnc(Oc2cccc(Cl)c2)nc1

InChI Key InChIKey=ZNCXWADVRHNBFT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588161   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588161(1-[(2S,3R)-3-[[6- [2-(3- chlorophenoxy) pyrimidin-...)
Affinity DataIC50: 6.88nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
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TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588161(1-[(2S,3R)-3-[[6- [2-(3- chlorophenoxy) pyrimidin-...)
Affinity DataIC50: 194nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent