BDBM588154 1-[3-[[6-[2-(3- fluorophenoxy) pyrimidin-5-yl]pyrazin- 2- yl]amino]azetidin- 1-yl]prop-2-en-1- one::US11542249, Example 25

SMILES Fc1cccc(Oc2ncc(cn2)-c2cncc(NC3CN(C3)C(=O)C=C)n2)c1

InChI Key InChIKey=PBZDGAXQEUUOPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588154   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588154(1-[3-[[6-[2-(3- fluorophenoxy) pyrimidin-5-yl]pyra...)
Affinity DataIC50: 19.3nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588154(1-[3-[[6-[2-(3- fluorophenoxy) pyrimidin-5-yl]pyra...)
Affinity DataIC50: 1.58E+3nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent