BDBM588140 1-[3-[[5-[2-(3-chloro- 4-fluoro- phenoxy)pyrimidin-5- yl]-3- pyridyl]amino]azetidin- 1-yl]prop-2-en-1-one::US11542249, Example 13

SMILES Fc1ccc(Oc2ncc(cn2)-c2cncc(NC3CN(C3)C(=O)C=C)c2)cc1Cl

InChI Key InChIKey=GPCYNXXZRBJCHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588140   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588140(1-[3-[[5-[2-(3-chloro- 4-fluoro- phenoxy)pyrimidin...)
Affinity DataIC50: 38.2nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588140(1-[3-[[5-[2-(3-chloro- 4-fluoro- phenoxy)pyrimidin...)
Affinity DataIC50: 450nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent