BDBM588127 3-[5-[5-[(1-prop-2- enoylazetidin-3- yl)amino]-3- pyridyl]pyrimidin-2- yl]oxybenzonitrile::US11542249, Example 3

SMILES C=CC(=O)N1CC(C1)Nc1cncc(c1)-c1cnc(Oc2cccc(c2)C#N)nc1

InChI Key InChIKey=AVCICDUXGRYQAB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588127   

TargetTyrosine-protein kinase BTK(Human)
Eli Lilly

US Patent
LigandPNGBDBM588127(3-[5-[5-[(1-prop-2- enoylazetidin-3- yl)amino]-3- ...)
Affinity DataIC50: 75.8nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM588127(3-[5-[5-[(1-prop-2- enoylazetidin-3- yl)amino]-3- ...)
Affinity DataIC50: 6.52E+3nMAssay Description:The BTK and EGFR biochemical assays utilize LANTHASCREEN Eu Kinase Binding Assays from Thermo Fisher Scientific, measuring the binding of the kinase ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent