BDBM588098 US11542247, Compound 1

SMILES COc1cc(CO)c2CN(CCN(c3ccc4ncc(cc4c3)-c3cnn(C)c3)c2c1)C(C)C

InChI Key InChIKey=JKCUPMBFCNGFCW-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 588098   

TargetFibroblast growth factor receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM588098(US11542247, Compound 1)
Affinity DataKd:  1.41E+3nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM588098(US11542247, Compound 1)
Affinity DataKd:  1.86E+3nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM588098(US11542247, Compound 1)
Affinity DataKd:  1.29E+3nMAssay Description:FGFR3: In a final reaction volume of 30 uL, FGFR3 (h) (40 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM588098(US11542247, Compound 1)
Affinity DataKd:  2.46E+3nMAssay Description:FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM588098(US11542247, Compound 1)
Affinity DataKd: >3.02E+3nMAssay Description:KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent