BDBM588052 (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide (Valemetostat)::US11535629, Compound Control B
SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@@]1(C)Oc2c(O1)c(C)c(cc2Cl)C(=O)NCc1c(C)cc(C)[nH]c1=O
InChI Key InChIKey=SSDRNUPMYCFXGM-UHFFFAOYSA-N
Data 45 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 588052
TargetHistone-lysine N-methyltransferase PRDM9(Homo sapiens)
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
Affinity DataIC50: 1.36nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as reduction in H3K27me3 levelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.440nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of wildtype EZH1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human EZH1 by radiometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 31.5nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
