BDBM588048 (R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)methyl)-2- (trans-4- (dimethylamino)cyclohexyl)-2,4- dimethyl-9-(1-methyl-1H-pyrrol- 2-yl)-7,8-dihydro- [1,3]dioxolo[4,5-g]isoquinolin- 5(6H)-one::US11535629, Compound 48

SMILES CN(C)[C@H]1CC[C@@H](CC1)[C@]1(C)Oc2c(O1)c(-c1cccn1C)c1CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c1c2C

InChI Key InChIKey=LRCKPDDIGDLQFW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588048   

TargetHistone-lysine N-methyltransferase EZH1(Human)
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588048((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50: 20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588048((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50: 3.30nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent