BDBM588042 6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)methyl)-2-(4- (dimethylamino)bicyclo[2.2.2]octan- 1-yl)-2,4,9-trimethyl-7,8-dihydro- [1,3]dioxolo[4,5-g]isoquinolin- 5(6H)-one isomer A::US11535629, Compound 23

SMILES CN(C)C12CCC(CC1)(CC2)C1(C)Oc2c(O1)c(C)c1C(=O)N(Cc3c(C)cc(C)[nH]c3=O)CCc1c2C

InChI Key InChIKey=HHSSNFZJCXGEOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588042   

TargetHistone-lysine N-methyltransferase EZH1(Human)
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50: 12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50: 0.590nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent