BDBM588033 9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan- 1-yl)-2,4-dimethyl-6-((6-methyl-4- (methylthio)-2-oxo-1,2- dihydropyridin-3-yl)methyl)-7,8- dihydro[1,3]dioxolo[4,5- g]isoquinolin-5(6H)-one isomer A::US11535629, Compound 8

SMILES CSc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)c3OC(C)(Oc3c(C)c2C1=O)C12CCC(CC1)(CC2)N(C)C

InChI Key InChIKey=CXLCYFIVMACFAK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 588033   

TargetHistone-lysine N-methyltransferase EZH1(Human)
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588033(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50: 167nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Hanmi Pharmaceutical

US Patent
LigandPNGBDBM588033(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50: 15nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent