BDBM587539 N-hydroxy-4-((3-(2- hydroxyphenethyl)-2,4- dioxo-3,4- dihydroquinazolin- 1(2H)- yl)methyl)benzamide::US11535598, Compound 18

SMILES ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccccc3O)c2=O)cc1

InChI Key InChIKey=NMIAETUCWFKGKM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 587539   

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 8.83E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 400nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 6nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 1.67E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 8.83E+3nMAssay Description:Inhibition of human HDAC1 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human HDAC6 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587539(US11535598, Compound 18 | N-hydroxy-4-((3-(2- hydr...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human HDAC8 expressed in baculovirus expression system in Sf9 cells using RHKAcKAc (379 to 382 residues) fluorogenic peptide as substra...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed