BDBM587522 4-((7-cyano-2,4-dioxo- 3-phenethyl-3,4- dihydroquinazolin- 1(2H)-yl)methyl)-N- hydroxybenzamide::US11535598, Compound 3

SMILES ONC(=O)c1ccc(Cn2c3cc(ccc3c(=O)n(CCc3ccccc3)c2=O)C#N)cc1

InChI Key InChIKey=DHWJPMDGGNEXEP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 587522   

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587522(US11535598, Compound 3 | 4-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 1.20E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587522(US11535598, Compound 3 | 4-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 1.30E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587522(US11535598, Compound 3 | 4-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 1.35E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587522(US11535598, Compound 3 | 4-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human HDAC1 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587522(US11535598, Compound 3 | 4-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 1.35E+4nMAssay Description:Inhibition of human HDAC6 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587522(US11535598, Compound 3 | 4-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human HDAC8 expressed in baculovirus expression system in Sf9 cells using RHKAcKAc (379 to 382 residues) fluorogenic peptide as substra...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed