BDBM586261 US11530244, Compound 346

SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](NC(=O)[C@H](CCCC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3cccc(CN)c3)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)[C@@H](C)O)cc1

InChI Key InChIKey=RZFKCVRKHPUZSA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 586261   

LigandPNGBDBM586261(US11530244, Compound 346)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
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LigandPNGBDBM586261(US11530244, Compound 346)
Affinity DataIC50: 6.55E+3nMAssay Description:The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent