BDBM586128 US11530244, Compound 046

SMILES CCC[C@@H]1NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@H]([C@@H](C)OC)N(C)C(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3cn(C)c4ccccc34)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@@H](CC(C)C)N(C)C1=O)C(N)=O)c2

InChI Key InChIKey=VEBUCFXLBZQBKJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 586128   

LigandPNGBDBM586128(US11530244, Compound 046)
Affinity DataIC50: 50nMAssay Description:A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
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LigandPNGBDBM586128(US11530244, Compound 046)
Affinity DataIC50: 50nMAssay Description:The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2023
Entry Details
Go to US Patent