BDBM585346 5-(4-(3-(2-fluoropyridin-4- yl)phenyl)piperazin-1- yl)pyrimidine-2,4-diamine::US11530198, Example 90

SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)-c2ccnc(F)c2)c(N)n1

InChI Key InChIKey=OIONZGABSWNRKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 585346   

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585346(US11530198, Example 90 | 5-(4-(3-(2-fluoropyridin-...)
Affinity DataIC50: 1.15E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585346(US11530198, Example 90 | 5-(4-(3-(2-fluoropyridin-...)
Affinity DataIC50: 42.7nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent