BDBM585345 5-(4-(3-(pyridazin-3- yl)phenyl)piperazin-1- yl)pyrimidine-2,4-diamine::US11530198, Example 107

SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)-c2cccnn2)c(N)n1

InChI Key InChIKey=OARVXBUGNHJOSK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 585345   

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585345(US11530198, Example 107 | 5-(4-(3-(pyridazin-3- yl...)
Affinity DataIC50: 1.59E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585345(US11530198, Example 107 | 5-(4-(3-(pyridazin-3- yl...)
Affinity DataIC50: 52.5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent