BDBM585318 5-(4-(3-(tetrahydro-2H-pyran-4- yl)phenyl)piperazin-1- yl)pyrimidine-2,4-diamine::US11530198, Example 110

SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)C2CCOCC2)c(N)n1

InChI Key InChIKey=JFIWMIVDCNPRTN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 585318   

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 6.17E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 34.7nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 7.76E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 7.94nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 7.76E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 1.10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent