BDBM585317 5-(4-(3-(2-ethylpyrimidin-5- yl)phenyl)piperazin-1- yl)pyrimidine-2,4-diamine::US11530198, Example 95

SMILES CCc1ncc(cn1)-c1cccc(c1)N1CCN(CC1)c1cnc(N)nc1N

InChI Key InChIKey=SPARCVYMDVDWRD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 585317   

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585317(US11530198, Example 95 | 5-(4-(3-(2-ethylpyrimidin...)
Affinity DataIC50: 1.59E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585317(US11530198, Example 95 | 5-(4-(3-(2-ethylpyrimidin...)
Affinity DataIC50: 7.24nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585317(US11530198, Example 95 | 5-(4-(3-(2-ethylpyrimidin...)
Affinity DataIC50: 1.41E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585317(US11530198, Example 95 | 5-(4-(3-(2-ethylpyrimidin...)
Affinity DataIC50: 3.80nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent